ea0006oc27 | Neuroendocrinology | SFE2003
Harmer S
, Bicknell A
The pro-opiomelanocortin (POMC)-derived peptides, pro-gamma-MSH and Lys-gamma3-MSH, have been shown to potentiate the steroidogenic action of Adrenocorticotropic hormone (ACTH) on the adrenal cortex. The molecular mechanisms for this potentiation are unclear, but it has been shown that gamma-MSH peptides promote mitochondrial cholesterol accumulation in the adrenal cortex by upregulating the activity of Hormone Sensitive Lipase (HSL) (1). HSL activity is regulated either by up...